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Public health relevance Given the magnitude of risks associated with alcohol use, and the generally poor communication of these risks to the target populations alcohol-related health outcomes (they are generally poor) when expressed as a measure of the number of cigarettes smoked, could resonate substantively better with the public than just straight statistics about alcohol consumptions harm

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Hypoxia induces p53 which mediates cellular apoptosis [18], both of which are upregulated in the Hallmark gene set analysis (i.e