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10.1007/s12033-023-00932-7 20 AtiaG

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Both activate AMPK, but through distinct mechanisms: metformin inhibits complex I of the mitochondrial electron transport chain, raising the cellular AMP:ATP ratio and thereby activating AMPK indirectly

Deboever N, Eisenberg MA, Antonoff MB, Hofstetter WL, Mehran RJ, Rice DC, Roth JA, Sepesi B, Swisher SG , Vaporciyan AA, Walsh GL, Rajaram R

Instead, your doctor will need to get a little creative, reporting that you have impaired glucose instead of type 1, and elaborating on post-meal blood glucose spikes, significant insulin resistance, and constant food cravings