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Pernicious anaemia is caused by a deficiency in vitamin B12, due to atrophic gastritis, an autoimmune condition (immune system destroys self), in this case the parietal cells of the stomach that produce intrinsic factor, a glycoprotein that binds to vitamin B12 in the stomach and is essential for normal absorption of vitamin B12 in the small intestine into the blood

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The NRF2-deficient mice did not spontaneously develop skin lesions (Fig

281,309 Moreover, reducing inflammation may slow down the degradation of joint cartilage, providing long-term joint protection

The stated rationale was safety: immunogenicity, manufacturing impurities, and thin human clinical data

An abstract of the study is online