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The problem with that assertion is that up to half the nicotine used in these products may still be derived from tobacco plants

Fertility Problems: Nicotine affects reproduction, decreasing sperm quality in men and adding complications to pregnancy in women

SECONDARY OUTCOMES: EFFECTS ON OTHERS You may not be blowing smoke when you chew tobacco but it does have its dangers to the people around you: No Tobacco SpittingSpitting in public is one of the unhealthiest means that spread environmental pollution and injure human health

MMWR Morb Mortal Wkly Rep (2010) 59:11416

However, most mechanistic insights derive from cigarette smoking and experimental models