Studies were divided between pre-clinical and mechanistic evidence, and clinical evidence
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Specific intestinal cells naturally produce GLP-1 after a meal, which activates GLP-1Rs throughout the body to stimulate insulin and suppress glucagon biosynthesis, delay gastric emptying, improve glucose metabolism, and increase satiety
Furthermore, tirzepatides efficacy in promoting weight loss raises the prospect of providing an alternative option to bariatric surgery for individuals seeking effective interventions against obesity
PCOS is primarily marked by ovarian dysfunction, which involves irregular follicle development and compromised function of ovarian granulosa cells (GCs) [4, 5]
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