Key Takeaways: Best Supplements to Take While on GLP-1 GLP-1 medications can be powerful tools for supporting weight loss and overall health, if done right
However, some people continue experiencing mild intermittent nausea, particularly if they eat too much at once or consume rich foods
For that reason, health care providers have used semaglutide for more than 15 years to treat Type 2 diabetes
Semaglutide does not typically have a direct effect on potassium levels
A further 12% were unsure
[11] In April 2026 the sponsor announced that SYNCHRONIZE-1 a double-blind, placebo-controlled study of roughly 725 adults with obesity or overweight without diabetes met its co-primary endpoints, reporting mean bodyweight loss of about 16.6% at 76 weeks versus about 3.2% on placebo, with a large proportion of participants achieving at least 5% weight loss