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Data and code availability The code generated during this study is available at METHOD DETAILS Hepatocyte specific model Starting with the thermodynamically curated human genome-scale Recon 3D 31,32 , we reconstructed a hepatocyte metabolic model by taking into account the physiology of hepatocytes and the genes expressed in liver cells

As with injectable Wegovy, individual results vary, and the medication is designed to be used alongside healthy lifestyle changes rather than as a standalone solution

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Regular follow-up appointments should be scheduled according to individual needs, typically every 3-6 months during the first year of GLP-1 therapy, with thyroid function testing as clinically indicated