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Ingenuity Pathway Analysis identified that CR levels were significantly correlated with altered nitrogen metabolism and, in particular, the purine metabolism, amino acid biosynthesis, urea cycle, and oxidative phosphorylation pathways (Figure 6A), as predicted by the transcriptional profiles of these tumors (Figure 4)

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[2] She rose to prominence with roles in the science fiction film Starship Troopers (1997), the erotic thriller film Wild Things (1998) and the James Bond film The World Is Not Enough (1999)

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As patients get older the site of bleeding tends to move back and can involve larger blood vessels