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Acutely increasing the tonic activity of VTA DA neurons using optogenetics is sufficient to mimic the behavioral bias (decreased exploration) induced by nicotine, suggesting that the DA control of the exploration/exploitation balance is altered by long-term nicotine exposure

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36 Further studies have suggested exposure to SHS may be linked to increased risks of some types of childhood cancer, 37 some types of cancer in adulthood, 2 emphysema in adulthood, 27 impaired sense of smell, 38 and may exacerbate chronic conditions such as sickle cell disease

If someone becomes acutely confused, aggressive, rigid, or collapses after smoking weed, do not assume its just THC