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Participants received once-weekly CagriSema, semaglutide 2.4 mg alone, cagrilintide 2.4 mg alone, or placebo, all in combination with lifestyle intervention

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This naturally occurring compound helps protect the body from oxidative stress, which can contribute to aging, inflammation and various chronic diseases

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reported that glucagon-induced insulin secretion was inhibited by Exendin 9-39 in purified rat beta-cells ( Nevertheless, the propensity for glucagon to augment insulin secretion through the beta-cell GLP-1R adds another layer of complexity to characterizing the physiological importance of alpha-cell-derived GLP-1 to the incretin effect