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Therefore, POL is probably a weaker detergent type of sclerosing solution than STS, and higher concentrations are necessary to produce complete vascular sclerosis

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The most common choice is 2 mL , which gives you a 5 mg/mL concentration

According to FDA labeling, metformin is contraindicated in patients with an estimated glomerular filtration rate (eGFR) below 30 mL/min/1.73 m or in those with acute or chronic metabolic acidosis