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69 Following this, a manufacturer must submit a report detailing the minor modification and establishing that FDA has determined that the product is exempt from demonstrating substantial equivalence to a predicate product

The most important sources and routes of microplastic absorption are shown in Figure 1

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Toxic compounds in cigarette butts can include formaldehyde, nicotine, arsenic, lead, copper, chromium, cadmium, and a variety of polyaromatic hydrocarbons (PAHs)