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"This leveling off of mutations could stem from these people having very proficient systems for repairing DNA damage or detoxifying cigarette smoke." This could explain why roughly 80 to 90 percent of smokers never develop lung cancer, while those that don't smoke at all still develop tumors

10.1002/eji.201141421 129 MeechR.MackenzieP

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The Institute of Medicine said the benefit to public health depends on the degree to which local and state governments change their policies. Overall, in the absence of transformative changes in the tobacco market, social norms and attitudes, or in the knowledge of patterns and causes of tobacco use, the committee is reasonably confident that raising the (minimum legal age) will reduce tobacco use initiation, particularly among adolescents 15 to 17 years of age