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Cotinine is produced when the body breaks down the nicotine found in tobacco smoke and second hand smoke can be detected by measuring its levels in saliva, blood or urine

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Effects of Smoking on the Lungs and Body People expose themselves to a variety of toxins by smoking cigarettes, e-cigs, marijuana, and cigars, as well as inhaling external smoke

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One of the interesting things about NRF2 is that it has deleterious effects on regulation of transporters such as multidrug resistance proteins (Mrps), which are known to be highly expressed at the neurovascular unit