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In vivo study revealed a dual inhibitory effect on both the formation of the NLRP3 and the activation of the JAK-STAT pathway inside the colon

Anti-PCSK9 antibodies, such as evolocumab and alirocumab, block the PCSK9 interaction with LDL receptor and have demonstrated robust LDL-C reductions in hypercholesterolemic patients 8

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In conclusion, TMAO plays a crucial role in the management and prognosis of ESRD

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