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So, with this imbalance, with the overexpression of these metalloproteinases especially metalloproteinases 1 and 3 there will be an excessive degradation of collagen

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It is easy to understand how tissues (like the lungs) which are directly contacted by smoke, are damaged, but scientists arent quite sure how tobacco can put someone at risk for cancers that develop in parts of the body that arent directly exposed to the tobacco smoke, such as the bladder and kidneys