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Primary Research Areas NNMT enzymology and pharmacology the lead first-in-class selective small-molecule NNMT inhibitor used to validate the entire target class [1,2]

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Conclusive associations are complicated by the fact that an important substrate of TMAO, choline, is an essential nutrient that is required for normal development of the brain [95]

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However, it will be interesting to see if Novo conducts a similar maintenance study that could shift the playing field in this vertical