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In addition, the released lactate can bind to the hydroxycarboxylic acid 1, HCA1 (encoded by the HCAR1 gene) receptor triggering autocrine effects in the adipocyte or paracrine effects in other cells

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The findings further revealed that older workers engaged in work at extremely high altitudes were more prone to cardiac abnormalities compared to younger workers (under 20 years old) who worked at altitudes below 4,000 m