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Oral antibiotics (doxycycline): While there are no direct drug interactions, nicotine's suppression of immune function and promotion of inflammation can undermine the anti-inflammatory effects of antibiotics, potentially making them less effective

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The group, based in the UK, were asked to produce treatment recommendations based on a systematic review of the evidence

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Publications from January 2010 to May 2025 were retrieved, with a particular emphasis on studies published within the past 5 years to capture the most recent advances