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Pregnant mice were exposed to 310 cigarettes daily from 7 days pre-mating to birth, and their offspring exhibited reduced ciliated cells, impaired alveolar development, and upregulated EGFR signaling [7]

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In addition, an industry-sponsored cross-sectional study of 459 Japanese individuals reported that exclusive HTP users had about 7 mg/dL higher HDL-C than cigarette smokers, with adjustment for age, sex, and BMI 10