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Mitochondria generate the majority of cellular ROS as a byproduct of oxidative phosphorylation, and mitochondrial GSH is the primary defense against this constant oxidative burden

Lab timing

Funding This work was supported by the National Natural Science Foundation of China (No

Simultaneously, some tumor cells, owing to specific mutations, elevated ROS levels and other unique biological features, exhibit ferroptosis susceptibility, with their survival hinging on the ferroptosis defense system (108)

Nat Cell Biol 20(2):186197 Shindo R, Kakehashi H, Okumura K et al (2013) Critical contribution of oxidative stress to TNF-induced necroptosis downstream of RIPK1 activation [J]

They have a higher respiratory-related mortality, they have a higher cancer-related mortality