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Children are much more prone to overdose because of their smaller body size

Conditional recommendations are made when the certainty of evidence is lower, when the margin between desirable and undesirable consequences is small and the balance depends on patient values and preferences, or when there is high variability in the values and preferences of patients

Establishments are required to post signs stating that sales to underage persons are prohibited.6 Self-service tobacco product displays are prohibited except in adult-only retail stores.6 The sale or distribution of electronic smoking devices to persons underage persons is prohibited.9 The sale or distribution of flavored electronic nicotine delivery systems or flavor enhancers restricted to sales by a smoking bar for on site consumption and sales of flavored electronic nicotine delivery devices to out-of-state purchasers.9 The sale of electronic nicotine delivery systems with nicotine content greater than 35 mg/ml is restricted to specialty tobacco stores and smoking bars.9 Redemption of discount coupons for electronic smoking devices is prohibited.9 Sampling or free distribution of electronic smoking devices is prohibited.9 Distribution of free samples in a retail or other commercial establishment is prohibited (except in retail tobacco stores and smoking bars).9 The sale of electronic cigarettes in health care institution buildings or grounds is prohibited.9 Mail-order or internet sales of electronic smoking devices are prohibited unless retailer requires age-verification and signature by person of legal sales age upon receipt.9 Local tobacco laws Brookline prohibits the sale of tobacco or e-cigarette products to anyone born after January 1, 2000.12 Blackstone, Brewster, Brookline, Canton, Chatham, Dedham, North Attleborough, Norwood, Sherborn, Wellesley, and Winthrop do not allow any retailer exemptions in their flavored tobacco laws.10 Bellingham, Blackstone, Deham, and Hull prohibit the sale of all e-cigarettes

Correction, January 30, 12 pm ET: A previous version of this story said Altria has a 35 percent stake in Juul

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