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Refined grains and fortified foods contain the synthetic form of folate, which individuals with MTHFR deficiency may struggle to process

However, patients with severe sulfur sensitivities or specific genetic mutations affecting sulfur metabolism (such as CBS gene upregulations) should consult their healthcare provider before initiating supplementation, as they may need to process sulfur pathways carefully

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But because it is not FDA-approved, any theoretical advantage can be outweighed by practical concerns about product quality and oversight