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Funding This research received no specific grant from any funding agency in the public, commercial, or not-for-profit sectors

[24] [25] According to a study published in 2019, disruption of mitochondrial homeostasis caused by NAD+ depletion is a significant contributor to the metabolic dysfunction in WS

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doi: 10.1093/cdn/nzaa040_092 119

However, because some MDHA will inevitably escape reduction and undergo dismutation, a backup system to deal with DHA is necessary (Fig