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[48] showed that human microglia cells accumulate microplastic, which is associated with an increase in pro-inflammatory response (increase in TNF-, IL-6, and IL-1 expression) and a decrease in anti-inflammatory response (decrease in TGF- and IL-10 expression)

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Generally, those who promote the social model approach to health argue for early intervention to stop illness or injury from occurring in the first place, this can be facilitated through legal and social changes like the smoking ban of 2007 or the introduction of compulsory car seat belt usage in 1983

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