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In their meta-analysis combining the results of twelve randomized controlled trials, Veronese and colleagues reported a significant decrease in depression severity after acetylcarnitine supplementation as monotherapy compared with placebo intake or no intervention [143]

The conversion of GSH to GSSG is traditionally viewed as being coupled to the clearance of reactive oxygen species (ROS) and the reduction of oxidized proteins (Figure 1A), positioning GSH as a key antioxidant that globally mitigates oxidative stress on proteins (13)

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The absence of this document leaves doubt about the reality of the analysis

10.1111/febs.13820 FEBS J

However, glutathione can slow down the process by fighting oxidative stress, which is regarded as one of the causes of early aging