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Simply put, synergism occurs when a mixture of chemicals produces a stronger effect than could otherwise have been predicted

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Huang X, Restuccia F, Gramola M, Rein G (2016) Experimental study of the formation and collapse of an overhang in the lateral spread of smouldering peat fires

For example, importing, exporting, and manufacturing tobacco requires you to obtain a federally-issued license from the Alcohol & Tobacco Tax and Trade Bureau (TTB)