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Abiraterone acetate (AA) followed by randomization to dasatinib (D) or sunitinib malate (S) in metastatic castrate resistant prostate cancer (mCRPC)
Methamphetamine's extreme addiction potential results from: Powerful Dopamine Release: Can cause extremely large increases in dopamine, far exceeding natural rewards Rapid Onset: Smoking or injecting produces immediate, intense euphoria Long Duration: Effects last 824 hours, enabling extended binges Severe Neurotoxicity: Causes lasting damage to dopamine and serotonin systems Cognitive Impairment: Memory, attention, and decision-making deficits can persist in recovery High Relapse Rates: Very high relapse rates within several years of treatment, according to NIDA research Methamphetamine is also increasingly implicated in overdose deaths rather than only in long-term harm, a shift driven largely by contamination of the stimulant supply with synthetic opioids
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