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The Boston native has inspired numerous meme templates over the years, which mostly bank on his humorously sad expressions that seem to be a daily occurrence for him (despite being married to actress and singer Jennifer Lopez)

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Figure 6 Number of studies analyzed that confirm the relationship between the use of EC and the consumption of conventional cigarettes and other substances DISCUSSION The present study posed the following research question: What are the risk and protective factors for e-cigarette use among adolescents, its association with tobacco and other substance use, and the evidence of its use as a smoking cessation strategy?