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Irritability often serves as an important criterion in diagnosing various adolescent psychiatric disorders, such as anxiety disorders, depression disorder, obsessive-compulsive disorder, attention-deficit/hyperactivity disorder, autism spectrum disorder, conduct disorder, and bipolar disorder, defined as an abnormal response to adversity or threat in individuals 7

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by 12 months, 57 had relapsed (51.8%)

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Am J Hum Genet (2016) 98(4):68096