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A study of 3D organotypic nasal epithelial culture showed that the impact of IQOS was substantially lower than CS in terms of cytotoxicity, tissue morphology, proinflammatory mediators, ciliary function, transcriptome perturbations, and miRNA expression profiles 59

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The figure below, from the IPCCs Fifth Assessment Report, shows the influence of different factors on temperature for the period from 1950 to 2010

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