Regardless of its source, nicotine is an addictive substance
doi:10 } : Cite journal requires |journal= (help) "Mortality from Smoking in Developed Countries 19502000: indirect estimates from national vital statistics" (PDF)
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This is likely due to the combination of chemicals, including nicotine, that can reduce blood flow and oxygen
In a mathematical analysis estimating the number of people who die in 1,000 years, researchers determined that the death rate was 9.7 per 1,000 person-years at risk for snus quitters and 18.7 for snus users
[In 1982] this Department issued a report in which it was estimated that tobacco use, particularly cigarette smoking, was related to 30 percent of all cancer deaths in the United States-a projected 129,000 premature deaths