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Bullae may rupture leading to pneumothorax Risk factor for COPD Cigarette smoking Occupational exposure (Coal dust, Silica) Indoor air pollution Recurrent infection Premature birth Alpha 1 antitrypsin deficiency IgA deficiency Etiology for Acute exacerbation of COPD Viral respiratory infections arethemost common cause of AECOPD, among them Rhinovirus isthe most common cause of acute exacerbation ofCOPD