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The absence of nicotine to affect the calming effect may result in an elevation of stress hormones such as cortisol that make it difficult to relax and sleep restoratively

doi:10.1093/ntr/ntab263

Someone who is very intoxicated through binge drinking or mixing alcohol with another depressant drug is at risk of alcohol poisoning, respiratory depression and death

4c) by EGFR TKI in TKI-resistant A549 and H460 cells under either low or high glucose condition