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Perhaps the enhanced fatigue resistance after smoking cessation is to some extent also attributable to the elevated haemoglobin concentration and haematocrit that enhance the oxygen carrying capacity and oxygen delivery with smoking cessation even above that seen in the non-smokers 17,53 , similar to that seen after doping with erythropoietin 71

And no, its not something that happens only to first time users

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Although comprehensive tobacco control efforts should address the entire population, the identified high-risk smoking subgroups may benefit from more focused and tailored behavioral interventions

PMID 9311925