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A consistently low temperature can be linked to several serious health conditions, such as: hypothyroidism adrenal insufficiency diabetes hypoglycemia sepsis pituitary insufficiency kidney failure anemia raynaud's disease liver failure malnutrition metabolic disorders Since the hypothalamus regulates body temperature by receiving signals from thermal receptors, hypothermia and prolonged low body temperature can also result from neurological disorders, such as: multiple sclerosis stroke parkinsons disease spinal cord injury intracranial bleeding Low body temperature due to medications and other substances Chronic alcohol consumption and drug use , especially over a long period, can also cause lowered body temperature

Activation of protein kinase C isoforms and its impact on diabetic complications

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