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After the entire process is over, different preparations of arecanut having different market value are prepared.[] Areca nut is believed to be strongly associated with development of oral submucous fibrosis (OSMF).[] Arecanut is mixed with variety of substances

6:CD007529

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Proinflammatory cytokines such as IL-2, IL-6, IL-9, and TNF- together with CXCL2 [macrophage inflammatory protein 2 (MIP-2)] secreted by macrophages, leukocytes, and cytokine-activated endothelial and epithelial cells play an important role in inflammatory cell recruitment (41)