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However, it has been shown that lung damage can induce central nervous system responses by activating specific neuronal pathways 16,17 , which include those linked to affective responses, such as anxiety and panic 18
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In a model of COPD with skeletal muscle dysfunction, CSE exposure induced downregulation of PCG-1 expression in C2C12 myotubes, accompanied by pathological changes, such as substantial reduction in myotube diameter and atrophy
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