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These unnecessary hospitalizations are the real cost of failing to enact comprehensive smoke-free legislation.The findings support the American Heart Associations position that smoke-freelaws should be comprehensive and apply to all workplaces and public environments, including restaurants, bars and casinos

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They further found that activation of the Wnt/-catenin signaling pathway in human airway epithelial cells from COPD smoking patients resulted in increased Vimentin expression, increased fibronectin release, and enhanced TGF-1/Smad signaling

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