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Eur Respir

Lung cancer is the most common consequence of tobacco addiction, and is responsible for approximately 154,000 deaths each year, while smoking is a leading cause of heart disease

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Clinical data also confirmed that the expressions of ZO-1, occludin, and E-cadherin was significantly down-regulated in the bronchial epithelium and lung tissues in COPD patients compared to healthy controls [5, 13, 14]