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NTZ effects were dose-dependent, where the higher dose was more efficient and closer to the effect of NAC or 4-PBA

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Livadas S, Pappas C, Karachalios A, Marinakis E, Tolia N, Drakou M (2014) Prevalence and impact of hyperandrogenemia in 1218 women with polycystic ovary syndrome

Quick Answer: Tirzepatide causes constipation in 12-26% of patients by slowing gastrointestinal motility through GLP-1 receptor activation, which delays transit time and increases water reabsorption from the colon

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