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Cigarette smoking is the leading cause of preventable death in the United States, accounting for more than 480,000 deaths annually, or one of every five deaths overall, according to the US Centers for Disease Control and Prevention (CDC)

According to Steenburgen, she, Caan and even Ferrell would sometimes "ruin a take a little bit from laughing," because "the visual" of Ferrell in costume as Buddy "was constantly funny." "You didn't really get used to it," she told PEOPLE

In those who received the inhibitor alone [and received a placebo tablet instead of the nicotine tablet], smoking decreased 30%. Figure 2

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In another study, early onset of smoking was the strongest predictor of high-risk behaviors among middle school students (DuRant et al