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Acknowledgements The authors thank Gregory Conner PhD for his insightful guidance and expertise, Professor Marianne Geiser for her valuable comments in preparing the manuscript, Nathalie Baumlin for her technical assistance with HBE cell cultures and Mir Anwar for his assistance with the fluorescence immunohistochemistry micrographs

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We can and should be doing a lot better in helping patients with smoking cessation after stroke. The researchers also found that stroke survivors who live in the Stroke Belt 8 states in the southeastern United States with elevated stroke rates (North Carolina, South Carolina, Georgia, Tennessee, Alabama, Mississippi, Arkansas and Louisiana) were around 6% less likely to have quit smoking than stroke survivors in other areas of the US

Given evidence of accelerated aging phenotype in Parkin / mice indicates that the maintenance of mitochondrial integrity and healthy aging requires Parkin-mediated mitochondrial quality control