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This explains why the magnitude is smaller than retatrutide, which adds direct glucagon receptor-mediated cardiac effects on top of the indirect GLP-1 effects

Kawai, B

Diabetes 50: 609613

Similar content being viewed by others Introduction As one of the most well-known class B1 G-protein-coupled receptors (GPCRs), the glucagon-like peptide-1 receptor (GLP-1R) is a clinically validated drug target for type 2 diabetes and obesity 1,2,3

Jensterle, M