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In terms of nicotine delivery from IQOS, a randomized crossover study showed that the nicotine delivery rate was similar between IQOS and CS with lower plasma nicotine peak after IQOS use (70% of CS peak) 87 , and another study reported a similar pharmacokinetic profile of nicotine from IQOS and CS with similar user satisfaction 88

Of the 148 included studies, 99 (67%) recruited male and female participants, 16 (11%) recruited only females and 7 (5%) recruited only males, while 26 (18%) did not report the sex of the participants