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Flavored vapes can contain nicotine, but its not a universal rule

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The study also analyzed biomarkers of recent tobacco use-serum cotinine, a major nicotine metabolite, and 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) in the urine, a tobacco-specific metabolite

Lung Growth in Childhood, Adolescence, and Early Adulthood Epidemiologic Evidence Evidence reviewed in the 1994 and 2004 Surgeon Generals reports (USDHHS 1994, 2004) demonstrated that active cigarette smoking during childhood and adolescence has the potential to slow the rate of lung growth and reduce the level of maximum lung function attained, thus increasing risk for development of chronic obstructive pulmonary disease (COPD) in adulthood

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national surveys and cognitively tested items from previous internal studies