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The JUUL users we studied obtained blood nicotine concentrations almost three times as high as most of the e-cigarette users we previously studied, Yingst said

It is also recognized that smoke exposure leads to the activation of the Nod-like receptor protein 3 (NLRP3) inflammasome [63], with consequent local generation of active interleukin 1 (IL-1), a process that induces inflammation and thereby can lead to both chronic fibrosis and cancer in mice [64]

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