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Due to thinning and sclerosis of the dermis, which remains over a long period of time, its blood supply is disturbed

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Together, these findings indicate that smoking even a small number of cigarettes per day has substantial negative health effects, Inoue-Choi said, and provide further evidence that smoking cessation benefits all smokers, regardless of how few cigarettes they smoke.

FDA will ensure that its review of cigarette plans will be completed no later than 6 months after receipt of an adequate plan from persons who work in good faith with FDA to complete its review (e.g., persons should work diligently with FDA and be responsive by submitting any requested information in a timely manner)