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The main one is that the chemicals (PM2.5, VOCs like phenanthrene, nitrogen species, heavy metals, carbon monoxide) can be breathed in and our immune system is activated since it sees these particles as foreign and that causes inflammation and could lead to asthma and activation of clotting cascades that could lead to heart attacks or strokes

Such is smoking cessation, and such is life

Smoking increases the hydroxylation of the hormone estradiol

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