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Therefore, deficiency of a critical autophagy gene, e.g., Atg5 , was expected to cause more severe injury after APAP overdose

Bulk RNA-sequencing analysis of the hippocampi revealed an enrichment of genes involved in neuronal synaptic plasticity ( homer1 ) 43 , autophagy ( mTOR ) 44 and learning and memory ( igf2r ) 45 in CD38- relative to IgG-injected mice (Supplementary Fig

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